Edge rusher Nick Bosa is out for Sunday's game against Arizona after straining his calf in practice; coach Kyle Shanahan said Bosa could miss several weeks for the unbeaten 49ers' defense.

QB Brock Purdy earned the weekly NFC honor after completing 20 of 22 passes with a rushing touchdown in a 35-13 win over Miami, as San Francisco also added DL Naquan Jones and returned WR Brandin Cooks to the practice squad.

San Francisco's pass rush takes a hit ahead of Sunday's home game as the coaching staff estimates a multi-week absence for its star edge rusher.

The NFL fined Juszczyk $14,926 for a beer-chugging-style touchdown celebration against Miami; he says he plans to appeal.

San Francisco's Sunday game includes a cultural celebration and a giveaway for the first 80,000 ticketed fans at Levi's Stadium.

San Francisco's Levi's Stadium opener featured Christian McCaffrey reaching 100 career touchdowns in a lopsided win. Head coach Kyle Shanahan praised quarterback Brock Purdy's performance as 'almost flawless.'

San Francisco placed receiver De'Zhaun Stribling on injured reserve after ankle surgery, with head coach Kyle Shanahan saying the team expects him back later this season.

Brock Purdy went 20-of-22 for 287 yards and 2 touchdowns as San Francisco improved to 2-0; Christian McCaffrey scored twice to reach 100 career touchdowns and George Kittle recorded his 600th career reception.