Los Angeles led 13-10 entering the fourth quarter before Buffalo's defense took over; Justin Herbert threw a red-zone interception that was returned 41 yards.

Two tight ends and a starting guard are out, gutting the Chargers' offensive line and pass-catching depth heading into their 0-3 hole.

A patchwork offensive line with a fourth-string left guard making his debut was exposed against Buffalo, though rookie S Genesis Smith forced a takeaway.

With four regulars unavailable, Los Angeles started a fourth-string left guard, directly explaining the winless start.

Los Angeles will be without TEs David Njoku and Charlie Kolar (both on IR) plus two projected offensive-line starters, leaving Oronde Gadsden II as the only healthy tight end for the 0-2 Chargers' trip to Buffalo.

The team's released depth chart lists two injured players as co-starters at tight end and shows an open competition at left guard between two currently hurt players, underscoring the roster's thin spots up front.

Coach Jim Harbaugh said the offense is still building timing and precision entering Week 3, citing a recent third-down execution issue as an example of the growing pains.

Los Angeles's offense ranks near the bottom of the league through two games, and the offensive coordinator says he and his quarterback regularly study film together ahead of Buffalo.

Los Angeles added a veteran receiver with two Super Bowl rings after losing a tight end to injured reserve.

Los Angeles fell to 0-2 after a 26-14 loss to Las Vegas, its second straight defeat. Cornerback Donte Jackson joined a local postgame broadcast to discuss the setback as the Chargers prepare to travel to Buffalo.

Los Angeles fell to 0-2 with a 26-14 loss to the Raiders at SoFi Stadium, its second straight loss by that exact score. Jackson discussed the team's response on NBC4's Postgame Live.