LB Matt Milano (pectoral) and DT Ed Oliver (ankle) will each miss a second straight game, while RT Spencer Brown and DE A.J. Epenesa are questionable, as the 2-0 Bills host New Orleans Sunday.

The Buffalo Bills organization, through GM Brandon Beane, publicly extended condolences to DT Ed Oliver and his family following the death of his son, saying the club would continue supporting the family through the loss. Coverage is limited strictly to the club's own on-record statement; no cause of death or further personal detail is reported.

Buffalo enters Week 3 unbeaten and is being warned by its own locker room not to overlook an 0-2 Chargers team seeking its first win.

Buffalo upgraded several banged-up starters to questionable while clearing a running back to make his 2026 debut against the Chargers.

Moore is a limited participant with a shoulder injury but said he plans to play Sunday against the Chargers as Buffalo tries to stay unbeaten at home.

WR Keon Coleman (ankle), DL Ed Oliver (hip) and DL T.J. Sanders (illness) did not practice, while Moore, Jordan Hancock and Ar'maj Reed-Adams were limited.

Buffalo has scored a league-high 77 points through two games but has also allowed 62, third-most in the NFL; DC Jim Leonhard says the unit needs to fix its issues.

Bills WR DJ Moore practiced in a limited, non-contact capacity Wednesday while managing a shoulder injury from Buffalo's Week 2 win over Detroit. Moore opened the season with 100 yards and a touchdown against Houston before going without a catch in Week 2.

Buffalo has scored an NFL-most 77 points through two games at its new Highmark Stadium but has also allowed 62, third-most in the league. Head coach Joe Brady and defensive coordinator Jim Leonhard both acknowledged the defense needs to tighten up despite the unbeaten start.

Buffalo has outscored everyone in the NFL (77 points through two games) but has allowed the third-most points (62). HC Joe Brady: "We're finding ways to win football games, and that's the most important thing." Buffalo hosts the Chargers next at the new Highmark Stadium.

LB Matt Milano (pectoral) and DT Ed Oliver (ankle) were ruled out ahead of Buffalo's Week 3 Thursday night home game vs. Miami; CB Taron Johnson, DB Cam Lewis and LB Shaq Thompson were listed questionable. Buffalo sits 2-0 atop the AFC East.